Can Fisetin Extend Healthspan and Enhance Longevity? 

By Dr. J.E. Williams | | Reading Time: 3 minutes

Fisetin - featured

Fisetin is a naturally occurring, plant-based flavonoid found in strawberries and other natural foods like apples, grapes, and onions. It’s relatively new as a supplement; however, as the most potent known natural senolytic, expect to hear more about fisetin. 

What Are Senolytics? 

Senolytics are molecules that selectively destroy old, dysfunctional senescent cells, allowing room for more healthy cells to prevent disease and promote longevity. But can taking fisetin reduce the impact of aging?

Researchers found that fisetin improves memory, restores skin health by protecting collagen, and removes dysfunctional aging cells. It also has cancer-preventative effects and may slow disease progression. And it protects the brain from the degenerative processes associated with aging. Fisetin may improve arterial function during aging. A few studies found that it can slow biological aging. 

Summary of Selected Research:

  • Improves artery function (Mahoney 2023)
  • Anticancer properties (Rengarajan 2016)
  • Reduces biological age (Lee 2024)
  • Extends health and lifespan (Yousefzadeh 2018)

Fisetin has multiple health benefits. It’s not just helpful in removing senescent cells. It can restore tissue health in older individuals to yield a potent healthy aging benefit.  

Benefits of Fisetin:

  • Destroys senescent cells to help you live longer
  • Helps improve glucose
  • Protects against osteoporosis
  • Brain protection
  • Improves memory
  • Improves heart health

Fisetin-Rich Foods:

  • Strawberries
  • Apples
  • Mangoes
  • Persimmons
  • Kiwis
  • Grapes 
  • Onions

Fisetin Supplements

Earlier, fisetin supplements required 1,500 mg daily to be effective. But newer, improved bioavailable forms are more absorbable.

I recommend 44.5 mg of Bio-Fisetin (one capsule) 2-3 times daily, with or without food. If you’re attempting to reverse a health condition, take two capsules each time for a total of 134 mg. 

A recent study (Lee 2024) found that 500 mg of fisetin daily reduced biological age, but some subjects showed an increase. Current research (Calabrese 2025) found that fisetin has multisystem effects in slowing aging. However, there is no consensus on an effective antiaging dose. Over time, both research and clinical evidence will reveal the best way to take fisetin. 

Fisetin is an example of a scientifically discovered, naturally occurring compound found in everyday foods that provides significant disease-preventive benefits. It’s currently considered the most potent senolytic. Research (Yousefzadeh 2018) suggests that it has benefits even when taken in advanced age.

We have more to learn about the longevity benefits of fisetin supplementation. However, it’s safe and is not associated with adverse effects. Including fisetin-rich foods in your diet and taking a fisetin supplement provides the best advantage. 

Get an email everytime there’s a new Dr. Williams post!

Selected References 

Calabrese EJ, Pressman P, Hayes AW, Agathokleous E, Dhawan G, Kapoor R, Parmar J, Mssillou I, Calabrese V. Fisetin: hormesis accounts for many of its chemoprotective effects. Biogerontology. 2025 Apr 10;26(2):90. http://doi:10.1007/s10522-025-10230-1. PMID: 40208387.

Lee E, Burns M. The Effects of Fisetin on Reducing Biological Aging: A Pilot Study. Altern Ther Health Med. 2024 Sep;30(9):6-10. PMID: 39269340.

Mahoney, S. A., Venkatasubramanian, R., Darrah, M. A., Ludwig, K. R., VanDongen, N. S., Greenberg, N. T., Longtine, A. G., Hutton, D. A., Brunt, V. E., Campisi, J., Melov, S., Seals, D. R., Rossman, M. J., & Clayton, Z. S. (2024). Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence. Aging Cell, 23(3), e14060. https://doi.org/10.1111/acel.14060

Pal HC, Pearlman RL, Afaq F. Fisetin and Its Role in Chronic Diseases. Adv Exp Med Biol. 2016;928:213-244. http://doi:10.1007/978-3-319-41334-1_10. PMID: 27671819. 

Rengarajan T, Yaacob NS. The flavonoid fisetin as an anticancer agent targeting the growth signaling pathways. Eur J Pharmacol. 2016 October 15;789:8-16. http://doi:10.1016/j.ejphar.2016.07.001. Epub 2016 July 2. PMID: 27377217.

Yousefzadeh MJ, Zhu Y, McGowan SJ, Angelini L, Fuhrmann-Stroissnigg H, Xu M, Ling YY, Melos KI, Pirtskhalava T, Inman CL, McGuckian C, Wade EA, Kato JI, Grassi D, Wentworth M, Burd CE, Arriaga EA, Ladiges WL, Tchkonia T, Kirkland JL, Robbins PD, Niedernhofer LJ. Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine. 2018 Oct;36:18-28. http://doi:10.1016/j.ebiom.2018.09.015. Epub 2018 September 29. PMID: 30279143; PMCID: PMC6197652.